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Article

Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate.

Nature reviews. Immunology - 1 Jul 2005

von Boehmer Harald

Abstract excerpt

The pre-T-cell receptor (pre-TCR) has a crucial role in the normal development of alphabeta T cells. Different views have emerged concerning the structure and function of the pre-TCR. This molecular complex can be viewed as a variant of the alphabeta-TCR in which the pre-TCR alpha-chain that is covalently associated with the TCR beta-chain is a 'surrogate' TCR alpha-chain. Alternatively, the unique structure of...

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Identifiers

PMID: 15999096
DOI: 10.1038/nri1636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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