Article
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.
Nature - 14 Oct 2010
Pang Siew Siew, Berry Richard, Chen Zhenjun, Kjer-Nielsen Lars, Perugini Matthew A, King Glenn F, Wang Christina, Chew Sock Hui, La Gruta Nicole L, Williams Neal K, Beddoe Travis, Tiganis Tony, Cowieson Nathan P, Godfrey Dale I, Purcell Anthony W, Wilce Matthew C J, McCluskey James, Rossjohn Jamie
Abstract excerpt
The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR β-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent αβ T-cell lineage differentiation. Whereas αβTCR ligation by the peptide-loaded major histocompatibility complex initiates T-cell signalling, pre-TCR-induced signalling occurs by...
Topics
- Crystallography, X-Ray
- Gene Rearrangement, T-Lymphocyte
- Humans
- Models, Molecular
- Mutation
- Protein Folding
- Protein Multimerization
- Protein Structure, Tertiary
- Receptors, Antigen, T-Cell