Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?

Molecular immunology - 1 Jun 2008

Cohn Melvin

Abstract excerpt

The postulate is analyzed that single V-gene segments encode recognition of the allele-specific determinants (a) required for the restrictive response of the alphabeta TCR to peptide. The consequence of this is that the positively selected V-domain, Valpha or Vbeta, engages an allele-specific determinant (a) on one subunit or domain of the MHC-encoded restricting element. The entrained V-domain docks on an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Codon
Share to Histocompatibility Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Immunological

Share to Protein Subunits

Share to Receptors, Antigen, T-Cell

Share to Receptors, IgG

Source

Open in PubMed Open full text

Identifiers

PMID: 18394705
DOI: 10.1016/j.molimm.2008.02.016
PMCID: PMC2464364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What does the T-cell receptor recognize when it docks on an MHC-encoded restricting element?PMID 18394705Read ↗

On a key postulate of T-cell receptor restrictive function: the V-gene loci act as a single pool encoding recognition of the polymorphic alleles of the species major histocompatibility complex.Semantic proximity Read ↗

An observation that illustrates most T cell receptor structure-function relationships.Semantic proximity Read ↗

A new twist in TCR diversity revealed by a forbidden alphabeta TCR.Semantic proximity Read ↗

Canonical structures for the hypervariable regions of T cell alphabeta receptors.Semantic proximity Read ↗

What is the selective pressure that maintains the gene loci encoding the antigen receptors of T and B cells? A hypothesis.Semantic proximity Read ↗

Ordered and coordinated rearrangement of the TCR alpha locus: role of secondary rearrangement in thymic selection.Semantic proximity Read ↗

Defining rules for the peptide-MHC class II interaction.Semantic proximity Read ↗

Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate.Semantic proximity Read ↗

HLA-DRB1 molecules and antigenic experience shape the repertoire of CD4 T cells.Semantic proximity Read ↗

Affinity maturation of lymphocyte receptors and positive selection of T cells in the thymus.Semantic proximity Read ↗

Models for antigen receptor gene rearrangement. I. Biased receptor editing in B cells: implications for allelic exclusion.Semantic proximity Read ↗

Structurally interdependent and independent regions of allelic polymorphism in class II MHC molecules. Implications for Ia function and evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.