Article
Allelic inclusion of T cell receptor alpha genes poses an autoimmune hazard due to low-level expression of autospecific receptors.
Immunity - 1 May 1998
Sarukhan A, Garcia C, Lanoue A, von Boehmer H
Abstract excerpt
Organ-specific autoimmune disease can be caused by alphabeta T cells that have escaped self-tolerance induction. Here we show that one of the causes of escape from self-tolerance is the coexpression of two different T cell receptors by the same cell, which can occur in up to 30% of all T cells in...
Topics
- Alleles
- Animals
- Autoimmunity
- CD4-Positive T-Lymphocytes
- Diabetes Mellitus, Type 1
- Hemagglutinin Glycoproteins, Influenza Virus
- Insulin
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Pancreas
- Promoter Regions, Genetic
- Rats
- Receptors, Antigen, T-Cell, alpha-beta
- Self Tolerance