Article
Structural and functional evolution of the extracellular regions of T cell receptors.
Seminars in immunology - 1 Dec 1994
Hein W R
Abstract excerpt
The primary structure of T cell receptor (TcR) heterodimers has been elucidated to varying degrees in 11 vertebrate species and the availability of these sequences provides a broader perspective for reassessing TcR evolution. Many features of the alpha beta TcR have been well conserved between divergent taxa whereas the structure and diversity of the gamma delta TcR is more variable. An alternative evolutionary...
Topics
- Amino Acid Sequence
- Animals
- Biological Evolution
- Genetic Variation
- Humans
- Molecular Sequence Data
- Receptors, Antigen, T-Cell
- Selection, Genetic
- Sequence Homology, Amino Acid