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Article

The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire.

Nature reviews. Immunology - 1 Jul 2005

Melchers Fritz

Abstract excerpt

In this Opinion article, I address the role of the pre-B-cell receptor (pre-BCR) in the development of antigen-specific B cells in terms of immunoglobulin heavy chain (IgH) variable-region repertoire selection, precursor B-cell differentiation and proliferation, and IgH allelic exclusion. Comparisons with the role of the pre-T-cell receptor (pre-TCR) in T-cell development raise provocative questions. Why do B-...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Membrane Glycoproteins

Share to Receptors, Antigen, B-Cell

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 15999097
DOI: 10.1038/nri1649

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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