Dual receptor T-cells. Implications for alloreactivity and autoimmunity.

doi:10.1111/j.1749-6632.1995.tb44482.x

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Article

Dual receptor T-cells. Implications for alloreactivity and autoimmunity.

Annals of the New York Academy of Sciences - 7 Jul 1995

Padovan E, Casorati G, Dellabona P, Giachino C, Lanzavecchia A

Abstract excerpt

Using monoclonal antibodies to human V alpha, we have estimated that up to one-third of mature T-cells express two V alpha chains as part of two functional and independent T-cell receptors. Cells belonging to this dual TCR subset may be specific for a broader range of antigens than cells with a s...

Topics

Alleles
Autoantigens
Autoimmunity
Cell Differentiation
Humans
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
Thymus Gland

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