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Article

The biological activity of natural and mutant pTalpha alleles.

The Journal of experimental medicine - 3 Sept 2001

Gibbons D, Douglas N C, Barber D F, Liu Q, Sullo R, Geng L, Fehling H J, von Boehmer H, Hayday A C

Abstract excerpt

beta selection is a major checkpoint in early thymocyte differentiation, mediated by successful expression of the pre-T cell receptor (TCR) comprising the TCRbeta chain, CD3 proteins, and a surrogate TCRalpha chain, pTalpha. The mechanism of action of the pre-TCR is unresolved. In humans and mice, the pTalpha gene encodes two RNAs, pTalpha(a), and a substantially truncated form, pTalpha(b). This study shows that...

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Identifiers

PMID: 11535637
DOI: 10.1084/jem.194.5.695
PMCID: PMC2195948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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