Article
Systemic lupus erythematosus--recent clues from congenic strains.
Archivum immunologiae et therapiae experimentalis - 1 Jan 2000
Henry Tamika, Mohan Chandra
Abstract excerpt
Systemic lupus erythematosus is a polycongenic autoimmune disease characterized by the production of antinuclear antibodies that lead to subsequent end organ damage. The study of lupus is complicated by its polycongenic origin, contributions from hormones and the environment, epistasis among susceptibility loci, suppressive modifiers, and the fact that a single susceptibility locus may encompass multiple...
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