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Article

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains

6 Jun 2000

Abstract excerpt

We previously produced three congenic strains carrying lupus susceptibility genes (Sle1-Sle3) from the lupus-prone NZM2410 mouse on the C57BL/6 background and characterized their component phenotypes. Sle1 mediates the loss of tolerance to nuclear antigens; Sle2 lowers the activation threshold of B cells; and Sle3 mediates a dysregulation of CD4(+) T cells. We have now created a collection of bi- and tricongenic...

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PMID: 10841565
DOI: 10.1073/pnas.97.12.6670

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