Article
The Lbw2 locus promotes autoimmune hemolytic anemia.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2012
Scatizzi John C, Haraldsson Maria K, Pollard K Michael, Theofilopoulos Argyrios N, Kono Dwight H
Abstract excerpt
The lupus-prone New Zealand Black (NZB) strain uniquely develops a genetically imposed severe spontaneous autoimmune hemolytic anemia (AIHA) that is very similar to the corresponding human disease. Previous studies have mapped anti-erythrocyte Ab (AEA)-promoting NZB loci to several chromosomal locations, including chromosome 4; however, none of these have been analyzed with interval congenics. In this study, we...
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