Article
Genetics of systemic autoimmunity in mouse models of lupus.
International reviews of immunology - 1 Jan 2000
Kono D H, Theofilopoulos A N
Abstract excerpt
Systemic lupus erythematosus (SLE) is inherited as a complex polygenic trait, involving genetic, environmental and stochastic factors. Although definition of these etiologic processes has been elusive, solid progress has been made toward elucidating the genetic basis for susceptibility. Herein, we summarize our genome wide mapping effort that has defined loci for component phenotypes for lupus-prone NZB, NZW,...
Topics
- Animals
- Autoimmunity
- Chromosome Mapping
- Disease Models, Animal
- Genetic Predisposition to Disease
- Humans
- Lupus Erythematosus, Systemic
- Mice
- Mice, Inbred MRL lpr
- Mice, Inbred NZB