Article
Genetics and systemic lupus erythematosus.
Current rheumatology reports - 1 Jun 2001
Tsao B P, Grossman J M
Abstract excerpt
Systemic lupus erythematosus (SLE) is a complex, multifactorial autoimmune disease. Genetic factors are believed to contribute to its pathogenesis. There have been numerous recent advances in the study of murine and human lupus genetics. In well-defined, experimental, transgenic or gene-knockout mouse models, the development of lupus-like disease has implicated specific genes and pathways in the disease...
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