Susceptibility to lupus nephritis in the NZB/W model system.

doi:10.1016/s0952-7915(98)80094-0

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Article

Susceptibility to lupus nephritis in the NZB/W model system.

Current opinion in immunology - 1 Dec 1998

Morel L, Wakeland E K

Abstract excerpt

Advances in genetic mapping have resulted in the identification of multiple lupus susceptibility loci in the NZB/W mouse model. The analysis of congenic strains carrying these loci is now providing functional data on their role in lupus pathogenesis and is paving the way to the identification of the susceptibility genes and their molecular characterization.

Topics

Animals
Disease Models, Animal
Disease Susceptibility
Genetic Linkage
Genetic Predisposition to Disease
Humans
Lupus Erythematosus, Systemic
Lupus Nephritis
Mice
Mice, Inbred NZB

Source

Open in PubMed

Identifiers

PMID: 9914223
DOI: 10.1016/s0952-7915(98)80094-0

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