Article
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 1996
Morel L, Yu Y, Blenman K R, Caldwell R A, Wakeland E K
Abstract excerpt
Systemic lupus erythematosus is inherited as a complex polygenic trait. Four genomic intervals containing major SLE-susceptibility loci were previously identified by interval mapping in the NZM2410 mouse model. In this paper, we utilized a marker-assisted selection protocol to produce four congen...
Topics
- Animals
- Antibodies, Antinuclear
- Autoimmune Diseases
- Chromatin
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Feasibility Studies
- H-2 Antigens
- Haplotypes
- Immunoglobulin G
- Lupus Erythematosus, Systemic
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NZB
- Mice, Mutant Strains
- Phenotype