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Article

Multiple roles of vertebrate REV genes in DNA repair and recombination.

Molecular and cellular biology - 1 Jul 2005

Okada Takashi, Sonoda Eiichiro, Yoshimura Michio, Kawano Yoshiaki, Saya Hideyuki, Kohzaki Masaoki, Takeda Shunichi

Abstract excerpt

In yeast, Rev1, Rev3, and Rev7 are involved in translesion synthesis over various kinds of DNA damage and spontaneous and UV-induced mutagenesis. Here, we disrupted Rev1, Rev3, and Rev7 in the chicken B-lymphocyte line DT40. REV1-/- REV3-/- REV7-/- cells showed spontaneous cell death, chromosomal instability/fragility, and hypersensitivity to various genotoxic treatments as observed in each of the single mutants....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15988022
DOI: 10.1128/MCB.25.14.6103-6111.2005
PMCID: PMC1168817

Genes

REV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple roles of vertebrate REV genes in DNA repair and recombination.PMID 15988022Read ↗

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Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.Semantic proximity Read ↗

Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis.Semantic proximity Read ↗

The property of DNA polymerase zeta: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle control.Semantic proximity Read ↗

Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs.Semantic proximity Read ↗

REV7 is required for processing AID initiated DNA lesions in activated B cells.Semantic proximity Read ↗

The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line.Semantic proximity Read ↗

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DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.Semantic proximity Read ↗

The Rad51 paralog Rad51B promotes homologous recombinational repair.Semantic proximity Read ↗

A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.Semantic proximity Read ↗

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