Article
Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.
DNA repair - 1 Jan 2000
Yamazoe Mitsuyoshi, Sonoda Eiichiro, Hochegger Helfrid, Takeda Shunichi
Abstract excerpt
In the 'post-genome' era, reverse genetics is one of the most informative and powerful means to investigate protein function. The chicken B lymphocyte line DT40 is widely used for reverse genetics because the cells have a number of advantages, including efficient gene targeting as well as a remarkably stable phenotype. Furthermore, the absence of functional p53 in DT40 cells enables identification of DNA damage...
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