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Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis.

Molecular cell - 9 Dec 2005

Kawamoto Takuo, Araki Kasumi, Sonoda Eiichiro, Yamashita Yukiko M, Harada Kouji, Kikuchi Koji, Masutani Chikahide, Hanaoka Fumio, Nozaki Kazuhiko, Hashimoto Nobuo, Takeda Shunichi

Abstract excerpt

Chicken B lymphocyte precursors and DT40 cells diversify their immunoglobulin-variable (IgV) genes through homologous recombination (HR)-mediated Ig gene conversion. To identify DNA polymerases that are involved in Ig gene conversion, we created DT40 clones deficient in DNA polymerase eta (poleta), which, in humans, is defective in the variant form of xeroderma pigmentosum (XP-V). Poleta is an error-prone...

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PMID: 16337602
DOI: 10.1016/j.molcel.2005.10.016

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