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Article

DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.

Immunologic research - 1 Jan 2008

Puebla-Osorio Nahum, Zhu Chengming

Abstract excerpt

Lymphocyte maturation requires generation of a large diversity of antigen receptors, which involves somatic rearrangements at the antigen receptor genes in a process termed V(D)J recombination. Upon encountering specific antigens, B-lymphocytes undergo rearrangements in the constant region of the immunoglobulin genes to optimize immune responses in a process called class switch recombination. Activated B-cells...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

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Share to Receptors, Antigen, B-Cell

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Source

Identifiers

PMID: 18214391
DOI: 10.1007/s12026-008-8015-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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