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Article

Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.

The Journal of biological chemistry - 27 Jan 2006

Takenaka Katsuya, Ogi Tomoo, Okada Takashi, Sonoda Eiichiro, Guo Caixia, Friedberg Errol C, Takeda Shunichi

Abstract excerpt

DNA lesions that escape excision repair pathways can cause arrested DNA replication. This replication block can be processed by translesion DNA synthesis (TLS), which is carried out by a number of specialized DNA polymerases. A sequential lesion bypass model has been proposed; one of the lesion-specific polymerases inserts nucleotide(s) opposite the damaged template, followed by extension from the inserted...

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Identifiers

PMID: 16308320
DOI: 10.1074/jbc.M506153200

Genes

POLK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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