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Article

The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line.

DNA repair - 1 Apr 2016

Mohiuddin, Kobayashi Shunsuke, Keka Islam Shamima, Guilbaud Guillaume, Sale Julian, Narita Takeo, Abdel-Aziz H Ismail, Wang Xin, Ogawa Saki, Sasanuma Hiroyuki, Chiu Roland, Oestergaard Vibe H, Lisby Michael, Takeda Shunichi

Abstract excerpt

The replicative DNA polymerases are generally blocked by template DNA damage. The resulting replication arrest can be released by one of two post-replication repair (PRR) pathways, translesion DNA synthesis (TLS) and template switching by homologous recombination (HR). The HERC2 ubiquitin ligase plays a role in homologous recombination by facilitating the assembly of the Ubc13 ubiquitin-conjugating enzyme with...

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Source

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Identifiers

PMID: 26994443
DOI: 10.1016/j.dnarep.2016.02.002
PMCID: PMC5351851

Genes

HERC2
RNF8
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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