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Article

Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.

The EMBO journal - 1 Apr 2003

Simpson Laura J, Sale Julian E

Abstract excerpt

The majority of DNA damage-induced mutagenesis in the yeast Saccharomyces cerevisiae arises as a result of translesion replication. This process is critically dependent on the deoxycytidyl transferase Rev1p, which forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p. To examine the role of Rev1 in vertebrate mutagenesis and the DNA damage response, we disrupted the gene in DT40 cells....

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Identifiers

PMID: 12660171
DOI: 10.1093/emboj/cdg161
PMCID: PMC152905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.PMID 12660171Read ↗

Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1.Semantic proximity Read ↗

Multiple roles of vertebrate REV genes in DNA repair and recombination.Semantic proximity Read ↗

The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase.Semantic proximity Read ↗

A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.Semantic proximity Read ↗

The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.Semantic proximity Read ↗

Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.Semantic proximity Read ↗

Post-replication repair in DT40 cells: translesion polymerases versus recombinases.Semantic proximity Read ↗

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient miceSemantic proximity Read ↗

Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates.Semantic proximity Read ↗

Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.Semantic proximity Read ↗

The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites.Semantic proximity Read ↗

The catalytic function of the Rev1 dCMP transferase is required in a lesion-specific manner for translesion synthesis and base damage-induced mutagenesis.Semantic proximity Read ↗

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