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Article

A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.

DNA repair - 1 Jan 2013

Kuang Lisha, Kou Haiping, Xie Zhongwen, Zhou Ying, Feng Xingang, Wang Lei, Wang Zhigang

Abstract excerpt

DNA damage tolerance consisting of template switching and translesion synthesis is a major cellular mechanism in response to unrepaired DNA lesions during replication. The Rev1 pathway constitutes the major mechanism of translesion synthesis and base damage-induced mutagenesis in model cell systems. Rev1 is a dCMP transferase, but additionally plays non-catalytic functions in translesion synthesis. Using the...

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Identifiers

PMID: 23142547
DOI: 10.1016/j.dnarep.2012.10.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.PMID 23142547Read ↗

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The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.Semantic proximity Read ↗

The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase.Semantic proximity Read ↗

Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1.Semantic proximity Read ↗

The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites.Semantic proximity Read ↗

[Induced mutagenesis and translesion DNA synthesis--structure and function of REV1].Semantic proximity Read ↗

Role of single-stranded DNA in targeting REV1 to primer termini.Semantic proximity Read ↗

Translesion Synthesis across Abasic Lesions by Human B-Family and Y-Family DNA Polymerases α, δ, η, ι, κ, and REV1Semantic proximity Read ↗

The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.Semantic proximity Read ↗

Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.Semantic proximity Read ↗

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