Article
REV7 is required for processing AID initiated DNA lesions in activated B cells.
Nature communications - 4 Jun 2020
Yang Dingpeng, Sun Ying, Chen Jingjing, Zhang Ying, Fan Shuangshuang, Huang Min, Xie Xia, Cai Yanni, Shang Yafang, Gui Tuantuan, Sun Liming, Hu Jiazhi, Dong Junchao, Yeap Leng-Siew, Wang Xiaoming, Xiao Wei, Meng Fei-Long
Abstract excerpt
Activation-induced cytidine deaminase (AID) initiates both antibody class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. DNA double-strand break response (DSBR) factors promote rearrangement in CSR, while translesion synthesis (TLS) polymerases generate mutations in SHM. REV7, a component of TLS polymerase zeta, is also a downstream effector of 53BP1-RIF1 DSBR pathway....
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