Article
Analysis of ras gene mutations in acute myeloid leukemia by the polymerase chain reaction and oligonucleotide probes.
Singapore medical journal - 1 Feb 1992
Chin Y M, Bosco J J, Koh C L
Abstract excerpt
In vitro deoxyribonucleic acid (DNA) amplification by the polymerase chain reaction (PCR) followed by hybridization with oligonucleotide probes were used to study ras gene mutations in acute myeloid leukemia (AML). The DNA of 30 AML patients at presentation of the disease at the University of Malaya Hospital, Kuala Lumpur were screened for ras gene mutations in codons 12, 13 and 61 of the N-ras, K-ras and H-ras...
Topics
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Female
- Genes, ras
- Humans
- Leukemia, Myeloid, Acute
- Leukemia, Myelomonocytic, Acute
- Leukemia, Promyelocytic, Acute