Article
Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia.
Oncology - 1 Jan 1992
Nakagawa T, Saitoh S, Imoto S, Itoh M, Tsutsumi M, Hikiji K, Nakamura H, Matozaki S, Ogawa R, Nakao Y
Abstract excerpt
We analyzed activating mutations of N-ras and K-ras by the polymerase chain reaction and oligonucleotide hybridization in hematological disorders. Activating mutations of these codons were detected in 4 of 20 cases of myelodysplastic syndrome (MDS) and 15 of 77 cases of acute myelogenous leukemia...
Topics
- Adult
- Aged
- Base Sequence
- DNA Mutational Analysis
- Female
- Genes, ras
- Humans
- Leukemia, Myeloid, Acute
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation