N-ras gene mutations in childhood acute non-lymphoblastic leukemia.

doi:10.1016/0145-2126(91)90170-x

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Article

N-ras gene mutations in childhood acute non-lymphoblastic leukemia.

Leukemia research - 1 Jan 1991

Terada N, Smith T J, Stork L C, Odom L F, Gelfand E W

Abstract excerpt

In view of the potential role for ras activation in leukemogenesis, we have screened a number of children with acute non-lymphoblastic leukemia (ANLL) for activating point mutations at codons 12, 13 and 61 of the N-ras proto-oncogene using panels of oligonucleotide probes in conjunction with poly...

Topics

Adolescent
Child
Child, Preschool
Codon
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Infant
Karyotyping
Leukemia, Myeloid, Acute
Leukocyte Count
Male
Mutation
Polymerase Chain Reaction
Proto-Oncogene Mas

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