Article
N-ras gene mutations in childhood acute non-lymphoblastic leukemia.
Leukemia research - 1 Jan 1991
Terada N, Smith T J, Stork L C, Odom L F, Gelfand E W
Abstract excerpt
In view of the potential role for ras activation in leukemogenesis, we have screened a number of children with acute non-lymphoblastic leukemia (ANLL) for activating point mutations at codons 12, 13 and 61 of the N-ras proto-oncogene using panels of oligonucleotide probes in conjunction with polymerase chain reaction (PCR) gene amplification. In contrast to the frequent occurrence (approximately 30%) of N-ras...
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