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Article

RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study.

Genes, chromosomes & cancer - 1 Jul 1990

Vogelstein B, Civin C I, Preisinger A C, Krischer J P, Steuber P, Ravindranath Y, Weinstein H, Elfferich P, Bos J

Abstract excerpt

Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, 13 in the KRAS gene, a...

Topics

Adolescent
Alleles
Child
Child, Preschool
Codon
DNA Mutational Analysis
DNA Probes
DNA, Neoplasm
Female
Genes, ras
Humans
Infant
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Polymerase Chain Reaction

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 2278970
DOI: 10.1002/gcc.2870020212

Genes

HRAS
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2278970-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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