Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study.

Genes, chromosomes & cancer - 1 Jul 1990

Vogelstein B, Civin C I, Preisinger A C, Krischer J P, Steuber P, Ravindranath Y, Weinstein H, Elfferich P, Bos J

Abstract excerpt

Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Child, Preschool

Share to DNA Mutational Analysis

Share to Infant

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 2278970
DOI: 10.1002/gcc.2870020212

Genes

HRAS
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study.PMID 2278970Read ↗

N-ras gene mutations in childhood acute non-lymphoblastic leukemia.Semantic proximity Read ↗

RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Analysis of ras gene mutations in childhood myeloid leukaemia.Semantic proximity Read ↗

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.Semantic proximity Read ↗

Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia.Semantic proximity Read ↗

The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing.Semantic proximity Read ↗

NRAS mutations in de novo acute leukemia: prevalence and clinical significance.Semantic proximity Read ↗

N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.Semantic proximity Read ↗

Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patientsSemantic proximity Read ↗

RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group.Semantic proximity Read ↗

Analysis of N-ras gene mutations in acute myeloid leukemia by allele specific restriction analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.