Article
The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing.
Blood - 15 Apr 1990
Ahuja H G, Foti A, Bar-Eli M, Cline M J
Abstract excerpt
DNA from 161 patients with various forms of hematologic malignancies were investigated for mutations in exons 1 and 2 of the N-RAS, K-RAS and Ha-RAS gene by direct sequencing of DNA amplified in vitro by the polymerase chain reaction. Mutations involving either codons 11, 12, or 13 of the N-RAS g...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Base Sequence
- Child
- DNA
- DNA, Neoplasm
- Female
- Genes, ras
- Hematologic Diseases
- Humans
- Leukemia
- Lymphoma
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Nucleic Acid Amplification Techniques