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Article

Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.

Blood - 15 Mar 1994

Neubauer A, Dodge R K, George S L, Davey F R, Silver R T, Schiffer C A, Mayer R J, Ball E D, Wurster-Hill D, Bloomfield C D

Abstract excerpt

Mutations of the N- and K-ras genes are the most frequent genetic aberrations in acute myeloid leukemia (AML) and their detection in preleukemic conditions such as the myelodysplastic syndrome (MDS) suggests a role in the earliest phases of leukemogenesis. Despite these observations, little is known about the clinical importance of ras mutations in AML. We studied the clinical impact of ras mutations in 99...

Topics

Adult
Aged
Female
Genes, ras
Humans
Leukemia, Myeloid, Acute
Male
Middle Aged
Mutation
Prognosis
Survival Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 8123851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8123851-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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