Analysis of ras gene mutations in childhood myeloid leukaemia.

Abstract excerpt

Previous studies have shown that approximately 30% of adult acute myeloid leukaemias and 20% of adult acute lymphoid leukaemias contain point mutated ras oncogenes. In order to assess whether ras oncogenes are also involved in childhood leukaemias, we have used polymerase chain reaction (PCR) amplification and synthetic oligonucleotide probes to study the nature and frequency of ras gene mutations in childhood...

Topics

• Acute Disease
• Child
• Child, Preschool
• Female
• Follow-Up Studies
• Genes, ras
• Humans
• Infant
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive
• Leukemia, Myeloid
• Male
• Mutation