Article
Analysis of N-ras gene mutations in acute myeloid leukemia by allele specific restriction analysis.
American journal of hematology - 1 Nov 1991
Todd A V, Ireland C M, Radloff T J, Kronenberg H, Iland H J
Abstract excerpt
N-ras gene activation occurs via single base substitutions in codons 12, 13, and 61. We have developed a rapid screening method, termed allele specific restriction analysis (ASRA), for detection of N-ras mutations at these three critical codons in acute myeloid leukemia (AML). Patient DNA samples...
Topics
- Acute Disease
- Alleles
- Codon
- Genes, ras
- Humans
- Leukemia, Myeloid
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotides
- Restriction Mapping