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Article

Analysis of N-ras gene mutations in acute myeloid leukemia by allele specific restriction analysis.

American journal of hematology - 1 Nov 1991

Todd A V, Ireland C M, Radloff T J, Kronenberg H, Iland H J

Abstract excerpt

N-ras gene activation occurs via single base substitutions in codons 12, 13, and 61. We have developed a rapid screening method, termed allele specific restriction analysis (ASRA), for detection of N-ras mutations at these three critical codons in acute myeloid leukemia (AML). Patient DNA samples are amplified by the polymerase chain reaction (PCR) by using primers that induce restriction sites in normal but not...

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PMID: 1951319
DOI: 10.1002/ajh.2830380310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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