Article
Mutation analysis of the ras gene in myelocytic leukemia by polymerase chain reaction and oligonucleotide probes.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Sept 1991
Liu T C, Lin S F, Chen T P, Liu H W, Chang J G
Abstract excerpt
Twenty-nine patients with acute myelocytic leukemia (AML) and 14 patients with Philadelphia chromosome-positive chronic myelocytic leukemia (CML) were analyzed to detect the presence of mutations in their ras genes by the polymerase chain reaction and oligonucleotide hybridization methods. Deoxyribonucleic acid (DNA) isolated from blood or bone marrow samples was screened for mutations in codons 12, 13 and 61 of...
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