Article
A role for decorin in the remodeling of myocardial infarction.
Matrix biology : journal of the International Society for Matrix Biology - 1 Jun 2005
Weis Sara M, Zimmerman Scott D, Shah Maithili, Covell James W, Omens Jeffrey H, Ross John, Dalton Nancy, Jones Ying, Reed Charles C, Iozzo Renato V, McCulloch Andrew D
Abstract excerpt
Because the small leucine-rich proteoglycan decorin has been implicated in regulation of collagen fibrillogenesis leading to proper extracellular matrix assembly, we hypothesized it could play a key role in cardiac fibrosis following myocardial infarction. In this study we ligated the left anterior descending coronary artery in wildtype and decorin-null mice to produce large infarcts in the anterior wall of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
