Article
Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice.
Circulation - 11 Sept 2001
Scherrer-Crosbie M, Ullrich R, Bloch K D, Nakajima H, Nasseri B, Aretz H T, Lindsey M L, Vançon A C, Huang P L, Lee R T, Zapol W M, Picard M H
Abstract excerpt
Background- To investigate the role of endothelial nitric oxide synthase (NOS3) in left ventricular (LV) remodeling after myocardial infarction (MI), the impact of left anterior descending coronary artery ligation on LV size and function was compared in 2- to 4-month-old wild-type (WT) and NOS3-deficient mice (NOS3(-/-)). Methods and Results- Two days after MI, both strains of mice had a similar LV size,...
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