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Article

Type I collagen cleavage is essential for effective fibrotic repair after myocardial infarction.

The American journal of pathology - 1 Nov 2011

Nong Zengxuan, O'Neil Caroline, Lei Ming, Gros Robert, Watson Alanna, Rizkalla Amin, Mequanint Kibret, Li Shaohua, Frontini Matthew J, Feng Qingping, Pickering J Geoffrey

Abstract excerpt

Efficient deposition of type I collagen is fundamental to healing after myocardial infarction. Whether there is also a role for cleavage of type I collagen in infarct healing is unknown. To test this, we undertook coronary artery occlusion in mice with a targeted mutation (Col1a1(r/r)) that yields collagenase-resistant type I collagen. Eleven days after infarction, Col1a1(r/r) mice had a lower mean arterial...

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Identifiers

PMID: 21907695
DOI: 10.1016/j.ajpath.2011.07.017
PMCID: PMC3204031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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