Article
Biglycan is required for adaptive remodeling after myocardial infarction.
Circulation - 11 Mar 2008
Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, Lüllmann-Rauch R, Lettau O, Jacoby C, Schrader J, Brand-Herrmann S-M, Young M F, Schultheiss H P, Levkau B, Baba H A, Unger T, Zacharowski K, Tschöpe C, Fischer J W
Abstract excerpt
BACKGROUND: After myocardial infarction (MI), extensive remodeling of extracellular matrix contributes to scar formation and preservation of hemodynamic function. On the other hand, adverse and excessive extracellular matrix remodeling leads to fibrosis and impaired function. The present study investigates the role of the small leucine-rich proteoglycan biglycan during cardiac extracellular matrix remodeling and...
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