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Article

Effects of biglycan deficiency on myocardial infarct structure and mechanics.

Molecular & cellular biomechanics : MCB - 1 Mar 2008

Campbell Patrick H, Hunt Darlene L, Jones Ying, Harwood Fred, Amiel David, Omens Jeffrey H, McCulloch Andrew D

Abstract excerpt

Biglycan, a small leucine-rich proteoglycan, has been shown to interact with extracellular matrix (ECM) collagen and may influence fibrillogenesis. We hypothesized that biglycan contributes to post-myocardial infarction (MI) scar development and that the absence of biglycan would result in altered scar structure and mechanics. Anterior MI was induced in biglycan hemizygous null and wild-type mice by permanent...

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Identifiers

PMID: 18524244
PMCID: PMC2679639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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