Article
Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction.
Journal of molecular and cellular cardiology - 1 Apr 2005
Ren Jie, Zhang Shaosong, Kovacs Attila, Wang Yibin, Muslin Anthony J
Abstract excerpt
Acute coronary occlusion results in ischemia-mediated death of cardiomyocytes. In the days and weeks following myocardial infarction (MI), left ventricular remodeling occurs that is characterized by persistent cardiomyocyte apoptosis, thinning and fibrosis at the site of infarction, ventricular chamber dilatation, and growth of remaining viable cardiomyocytes. The p38 mitogen-activated protein kinase (MAPK)...
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