Article
Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice.
Circulation - 7 Aug 2001
Feng Q, Lu X, Jones D L, Shen J, Arnold J M
Abstract excerpt
BACKGROUND: Inducible nitric oxide synthase (iNOS) is expressed in the myocardium after myocardial infarction (MI) and in heart failure. Its pathophysiological role in these conditions, however, is not clear. We hypothesized that increased NO production from iNOS expression causes myocardial dysf...
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