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Article

A collagen α2(I) mutation impairs healing after experimental myocardial infarction.

The American journal of pathology - 1 Jan 2012

Hofmann Ulrich, Bonz Andreas, Frantz Stefan, Hu Kai, Waller Christiane, Roemer Katrin, Wolf Jürgen, Gattenlöhner Stefan, Bauersachs Johann, Ertl Georg

Abstract excerpt

Collagen breakdown and de novo synthesis are important processes during early wound healing after myocardial infarction (MI). We tested the hypothesis that collagen I, the main constituent of the extracellular matrix, affects wound healing after MI. The osteogenesis imperfecta mouse (OIM), lacking procollagen-α2(I) expression, represents a model of the type III form of the disease in humans. Homozygous (OIM/OIM),...

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Source

Identifiers

PMID: 22067913
DOI: 10.1016/j.ajpath.2011.09.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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