Proteomic analysis identifies <i>in vivo</i> candidate matrix metalloproteinase‐9 substrates in the left ventricle post‐myocardial infarction

Abstract excerpt

Matrix metalloproteinase-9 (MMP-9) deletion has been shown to improve remodeling of the left ventricle post-myocardial infarction (MI), but the mechanisms to explain this improvement have not been fully elucidated. MMP-9 has a broad range of in vitro substrates, but relevant in vivo substrates are incompletely defined. Accordingly, we evaluated the infarct regions of wild-type (wt) and MMP-9 null (null) mice...

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