Article
Isolation of genes specifically expressed in flat revertant cells derived from activated ras-transformed NIH 3T3 cells by treatment with azatyrosine.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1992
Krzyzosiak W J, Shindo-Okada N, Teshima H, Nakajima K, Nishimura S
Abstract excerpt
We previously reported that mouse NIH 3T3 cells transformed by transfection of activated human c-Ha-ras become apparently normal upon treatment with the antibiotic azatyrosine. The revertant cells maintain their normal phenotype during prolonged culture in the absence of azatyrosine, although activated p21ras is still expressed. The normal phenotype induced by azatyrosine could be due to activation of expression...
Topics
- 3T3 Cells
- Alanine
- Animals
- Base Sequence
- Cell Transformation, Neoplastic
- Cloning, Molecular
- Collagen
- Fibronectins
- GTP-Binding Proteins
- Gene Expression