Article
Retinoic acid-induced differentiation of a nontumorigenic embryonal carcinoma cell mutant created through retroviral insertion.
Experimental cell research - 1 Apr 1992
Dietrich J, Shin H S, McCormick P J
Abstract excerpt
A mutant embryonal carcinoma cell line, NR1-6, was created through retroviral insertion. We have previously reported that due to a single insertional event the mutant cell line is altered in regard to both its morphology and its tumorigenic capacity. We now report that this same cell line is also aberrant in its differentiative potential following exposure to the morphogen retinoic acid (RA). Unlike the parental...
Topics
- Animals
- Blotting, Northern
- Cell Differentiation
- Collagen
- Genes, Viral
- Laminin
- Mice
- Mutagenesis, Insertional
- Phenotype
- Proto-Oncogene Proteins c-myc
- RNA, Messenger