Article
Reversion of transformed phenotype of human adenocarcinoma A549 cells by expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase complementary DNA.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1995
Seronie-Vivien S, Pradines A, Couderc B, Clamagirand C, Berg D, Soula G, Favre G
Abstract excerpt
3-Hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase) plays a rate-limiting role in isoprenoid biosynthesis and is associated with cell proliferation and transformation. Although an elevated level of HMG-CoA reductase activity is consistently detected in cancer cell lines and tumors, the question remains whether HMG-CoA reductase activity may have a causative role in cell transformation. We have stably...
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