Article
Reversion of transformed phenotype of human adenocarcinoma A549 cells by expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase complementary DNA.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1995
Seronie-Vivien S, Pradines A, Couderc B, Clamagirand C, Berg D, Soula G, Favre G
Abstract excerpt
3-Hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase) plays a rate-limiting role in isoprenoid biosynthesis and is associated with cell proliferation and transformation. Although an elevated level of HMG-CoA reductase activity is consistently detected in cancer cell lines and tumors, the q...
Topics
- Acyl Coenzyme A
- Adenocarcinoma
- Agar
- Animals
- Cell Division
- Cell Line, Transformed
- Cloning, Molecular
- Cytoskeleton
- DNA, Complementary
- Humans
- Kinetics
- Lung Neoplasms
- Mice
- Mice, Nude
- Oxidoreductases