Article
Functional identification and molecular cloning of a rat gene mediating growth inhibition and programmed cell death in normal and transformed rat cell lines.
Oncogene - 1 Mar 1994
Schwarte-Waldhoff I, Martin W, Willecke K, Schäfer R
Abstract excerpt
We wished to identify DNA sequences conferring suppression of proliferation and transformed phenotypes. Thus, we have transfected DNA from normal rat cells, covalently linked to neo DNA coding for neomycin resistance into a tumorigenic, HRAS transformed rat cell line. Phenotypic revertants were s...
Topics
- Animals
- Apoptosis
- Cell Division
- Cell Line
- Cell Line, Transformed
- Cloning, Molecular
- DNA
- Drug Resistance
- Genes, ras
- Neomycin
- Oncogene Protein gp140(v-fms)
- Oncogene Proteins v-raf
- Oncogenes
- Phenotype
- Protein-Tyrosine Kinases
- Rats
- Retroviridae Proteins, Oncogenic
- Transfection