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Article

Functional identification and molecular cloning of a rat gene mediating growth inhibition and programmed cell death in normal and transformed rat cell lines.

Oncogene - 1 Mar 1994

Schwarte-Waldhoff I, Martin W, Willecke K, Schäfer R

Abstract excerpt

We wished to identify DNA sequences conferring suppression of proliferation and transformed phenotypes. Thus, we have transfected DNA from normal rat cells, covalently linked to neo DNA coding for neomycin resistance into a tumorigenic, HRAS transformed rat cell line. Phenotypic revertants were selected after the first cycle of transfection by enrichment procedures that served to eliminate transformed cells. The...

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PMID: 8108134

Genes

HRAS

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