Article
Identification and characterization of genes whose expressions are altered in rat 6 fibroblasts transformed by mutant p53(val135).
Biochemical and biophysical research communications - 20 Dec 1999
Yam J W, Zheng J Y, Hsiao W L
Abstract excerpt
The wild-type tumor suppressor gene p53 is known as a transcription factor in activating or suppressing target genes that encode proteins in regulating genome stability, DNA damage, cell arrest, and apoptosis. However, the role of mutant p53 in the process of cell transformation is still unclear. Our recent work indicated that overexpression of mutant p53(val135) induced high incidence of spontaneous...
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