Article
Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation.
Molecular and cellular biology - 1 Sept 1992
Cutler M L, Bassin R H, Zanoni L, Talbot N
Abstract excerpt
Using an expression cloning assay, we have isolated a novel cDNA, referred to as rsp-1, which suppresses the v-Ras-transformed phenotype. When introduced into NIH 3T3 fibroblasts under the control of a metallothionein promoter, rsp-1 confers resistance to v-Ras, but not to v-Mos or v-Src, and inhibits growth of the cells. The rsp-1 cDNA contains a 831-bp open reading frame encoding a 277-amino-acid leucine-rich...
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