Article
Isolation of rsp-1, a novel cDNA capable of suppressing v-Ras transformation.
Molecular and cellular biology - 1 Sept 1992
Cutler M L, Bassin R H, Zanoni L, Talbot N
Abstract excerpt
Using an expression cloning assay, we have isolated a novel cDNA, referred to as rsp-1, which suppresses the v-Ras-transformed phenotype. When introduced into NIH 3T3 fibroblasts under the control of a metallothionein promoter, rsp-1 confers resistance to v-Ras, but not to v-Mos or v-Src, and inh...
Topics
- 3T3 Cells
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cloning, Molecular
- DNA
- Genes, Regulator
- Genes, ras
- Humans
- Mice
- Molecular Sequence Data
- Phenotype