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Article

Induction of putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted complex hybridization.

Journal of molecular medicine (Berlin, Germany) - 1 Jan 2000

Heinrich J, Bosse M, Eickhoff H, Nietfeld W, Reinhardt R, Lehrach H, Moelling K

Abstract excerpt

The growth factor receptor-dependent protein kinase Raf-1 is activated by GTP-bound Ras, thereby activating the mitogen-activated protein kinase pathway. To study the role of Raf in transformation we transduced Rat-1 cells with a tetracycline-regulatable retroviral vector encoding the constitutively active oncogenic C-terminal fragment of the human Raf-1 protein. Using subtractive hybridization of mRNAs from...

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PMID: 11043381
DOI: 10.1007/s001090000116

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