Article
SUMO modification of PCNA is controlled by DNA.
The EMBO journal - 17 Sept 2008
Parker Joanne L, Bucceri Andrea, Davies Adelina A, Heidrich Katharina, Windecker Hanna, Ulrich Helle D
Abstract excerpt
Post-translational modification by the ubiquitin-like protein SUMO is often regulated by cellular signals that restrict the modification to appropriate situations. Nevertheless, many SUMO-specific ligases do not exhibit much target specificity, and--compared with the diversity of sumoylation substrates--their number is limited. This raises the question of how SUMO conjugation is controlled in vivo. We report here...
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